One-Pot Synthesis of Conjugated (E)-Enynones via Two Types of Cross-Coupling Reaction
摘要：
(Trimethylsilyl)ethynyl bromide can be easily trans-formed into conjugated (E)-enynones, whose skeleton consists of consecutive carbonyl, ethynyl, and (E)-ethenyl units, via a one-pot multi component Suzuki-type reaction-Sonogashira reaction se-quence. Thus, a three-component coupling of (trimethylsilyl)ethy-nyl bromide, (E)-alk-l-enyldisiamylborane and acid chloride is achieved in a two-step, one-pot procedure, in which (E)-alk- 1 -enyl group is installed as nucleophile in the sp-carbon atom attached to bromine atom and acyl group is installed as electrophile in the other sp-carbon atom.
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年份：
2010
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