Silica sulfuric acid as a reusable heterogeneous catalyst for the diastereoselective Mukaiyama aldol reaction of 2-(trimethylsilyloxy)furan: facile synthesis of γ-butenolides
摘要：
Silica sulfuric acid was found to be an efficient catalyst for the vinylogous Mukaiyama aldol reaction of 2-(trimethylsilyloxy)furan with various aldehydes with good diastereoselection. The reaction proceeds rapidly in THF, affording the corresponding 5-(arylhydroxymethyl)furan-2(5 H )-ones in good yields. This method offers significant advantages such as experimental simplicity, and recoverability and reusability of the catalyst. Graphical
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关键词：
2 (trimethylsilyloxy)furan Aldehydes Diastereoselectivity γ Butenolides Vinylogous Mukaiyama aldol reaction
DOI：
10.1007/s00706-010-0388-z
被引量：
年份：
2010
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