Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS.

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48

摘要:

Motivation: Epistasis, the presence of gene–gene interactions, has been hypothesized to be at the root of many common human diseases, but current genome-wide association studies largely ignore its role. Multifactor dimensionality reduction (MDR) is a powerful model-free method for detecting epistatic relationships between genes, but computational costs have made its application to genome-wide data difficult. Graphics processing units (GPUs), the hardware responsible for rendering computer games, are powerful parallel processors. Using GPUs to run MDR on a genome-wide dataset allows for statistically rigorous testing of epistasis.[ABSTRACT FROM PUBLISHER]

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DOI:

10.1093/bioinformatics/btq009

被引量:

108

年份:

2010

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