Lipase catalyzed esterification of glycidol in organic solvents

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摘要：

We studied the resolution of racemic glycidol through esterification with butyric acid catalyzed by porcine pancreatic lipase in organic media. A screening of seven solvents (log P values between 0.49 and 3.0, P being the n-octanol-water partition coefficient of the solvent) showed that neither log P nor the logarithm of the molar solubility of water in the solvent provides good correlations between enantioselectivity and the properties of the organic media. Chloroform was one of the best solvents as regards the enantiomeric purity (e. p.) of the ester produced. In this solvent, the optimum temperature for the reaction was determined to be 35°C. The enzyme exhibited maximum activity at a water content of 13 ± 2% (w/w). The enantiomeric purity obtained was 83 ± 2% of (S)-glycidyl butyrate and did not depend on the alcohol concentration or the enzyme water content for values of these parameters up to 200 mM and 25% (w/w), respectively. The reaction was found to follow a BiBi mechanism. ? 1993 John Wiley & Sons, Inc.

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关键词：

glycidol enantioselective esterification lipase organic solvents

DOI：

10.1002/bit.260420409

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年份：

2010