Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives
摘要：
at submicro molar level and about tenfold weaker inhibition versus SHP-1, but almost no inhibition against SHP-2. Kinetic analysis indicates that they are reversible competitive inhibitors of PTP1B. Fluorescence study on the interaction between PTP1B and complex or suggests that the complexes bind to PTP1B with the formation of a 1:1 complex. The binding constant are about 1.14×10 and 1.87×10 M at 310K for and , respectively.
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DOI：
10.1007/s10534-011-9460-3
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年份：
2011
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来源期刊
Biology of Metals
2011/05/27
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2012
被引量：15
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