Genetic Complementation
摘要：
Generally speaking, genes, in the sense of units carrying the genetic information for single specific macromoleeules (RNA and protein), can be defined by complementation tests. Genomes with mutational damage in different genes are complementary while those mutant in the same gene are not. Apparent inconsistencies in complementation patterns are due to two important complications in the relations of genes with their products: (a) several adjacent genes may (at least in bacteria) be transcribed as a unit to form a single molecule of messenger RNA (operon); and (b) the primary products of genes are messenger RNA sequences specifying single polypeptide chains, the functional products, however, are proteins, which are usually aggregates of polypeptide chains; unexpected complementary interactions between products of different mutant forms of the same gene products can sometimes occur at the aggregation stage.
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DOI：
10.1038/227751a0
被引量：
年份：
1968
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