Nucleoside transport in cultured mammalian cells multiple forms with different sensitivity to inhibition by nitrobenzylthioinosine or hypoxanthine

The zero- trans influx of 500 渭M uridine by CHO, P388, L1210 and L929 cells was inhibited by nitrobenzylthioinosine (NBTI) in a biphasic manner; 60鈥 70% ...

PGW Plagemann，RM Wohlhueter - 《Biochimica Et Biophysica Acta》

Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase.

(0.02) >> S6-methyl-6-thiohypoxanthine (S6mH), O6-methyl-1-deazaguanine (O6m1DG), O6-methyl-3-deazaguanine (O6m3DG), and O6-methyl-7-deaza...

TE Spratt，JD Wu，DE Levy，... - 《Biochemistry》

Properties of the thymidine transport system of Chinese hamster ovary cells as probed by nitrobenzylthioinosine

The transport of thymidine into Chinese hamster ovary cells grown in suspension culture was measured under conditions in which thymidine was not metabolized, namely, when cells had been depleted of ATP. The system transporting thymidine ...

RM Wohlhueter，R Marz，PGW Plagemann - 《Journal of Membrane Biology》

Thioguanine, Mercaptopurine: Their Analogs and Nucleosides as Antimetabolites

6-Mercaptopurine (6MP) and 6-thioguanine (6TG) are analogs of the natural purines: hypoxanthine and guanine. Both mercaptopurine and thioguanine are substr...

Elgemeie，Galal - 《Current Pharmaceutical Design》

2-Alkyloxyalkylthiohypoxanthines as new potent inhibitors of xanthine oxidase

The title compounds were prepared and tested as xanthine oxidase (XO) inhibitors. Results evidenced that potency was related to the position of the oxygen ...

G Biagi，I Giorgi，F Pacchini，... - 《IL Farmaco》

Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity

(assigned to Euro-Celtique, S. A. and incorporated by reference in its entirety herein) that the analogous transformation of 3 and 3,8-di-substituted thiohypoxanthines into the corresponding purine derivatives gives compounds having PDE ...

M Chasin，D Cavalla，P Hofer - EP

Demonstration of the adenosine reservoirs with nitrobenzylthioinosine in liver and diaphragm by high-performance liquid chromatography

Purine nucleotides, nucleosides, nucleobases, dinucleotides and nucleosides derivatives from acid-extracted rat liver and diaphragm were separated and quan...

Ronald，L.，Jenkins，... - 《Journal of Chromatography B Biomedical Sciences & Applications》