Activated ras Prevents Downregulation of Bcl-XL Triggered by Detachment from the Extracellular Matrix: A Mechanism of ras-induced Resistance to Anoikis in Intestinal Epithelial Cells
摘要：
Examines the mechanism of ras during downregulation of the antiapoptotic protein Bcl-XL in nonmalignant rat and human intestinal epithelial cells. Presence of anoikis after detachment of epithelial cells from the extracellular matrix; Resistance to anoikis after transformation of the cell by ras oncogenes; Ability of ras to regulate Bcl-XL and Bak expression.
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关键词：
Apoptosis Cell Transformation Neoplastic Extracellular Matrix Genes ras 脱噬作用 细胞转化 肿瘤 细胞外基质 基因 RAS 肠粘膜 原致癌基因蛋白质 c-bcl-2
DOI：
10.1083/jcb.149.2.447
年份：
2000
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