The Deracemization of Secondary Alcohols via a Chemo-Enzymatic Process
摘要：
Optically pure secondary alcohols were efficiently prepared via a two-step, one-pot process involving a chemical oxidative agent in combination with an enantioselective ketone reducase Rhodotorula sp. AS2.2241 in tandem. The reaction proceeded successfully with 88 similar to 99.5% enantiomeric excess in moderate to good conversions. A variety of substrates, including aromatic and aliphatic alcohols, could be tolerated.
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关键词：
Deracemization oxidative agent Rhodotorula sp AS2.2241 chemo-enzymatic one-pot secondary alcohols OXIDATIVE KINETIC RESOLUTION ENANTIOSELECTIVE AEROBIC OXIDATION RHODOTORULA SP AS2.2241 ASYMMETRIC REDUCTION KETONES DERACEMISATION EFFICIENT ACETOPHENONE COMPLEXES EVOLUTION
DOI：
10.2174/157017808786857516
年份：
2008
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