The Deracemization of Secondary Alcohols via a Chemo-Enzymatic Process

作者:

X WuJ XinL ZhuC Branford-WhiteW SunJ XuC Xia

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摘要:

Optically pure secondary alcohols were efficiently prepared via a two-step, one-pot process involving a chemical oxidative agent in combination with an enantioselective ketone reducase Rhodotorula sp. AS2.2241 in tandem. The reaction proceeded successfully with 88 similar to 99.5% enantiomeric excess in moderate to good conversions. A variety of substrates, including aromatic and aliphatic alcohols, could be tolerated.

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DOI:

10.2174/157017808786857516

年份:

2008

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