The Deracemization of Secondary Alcohols via a Chemo-Enzymatic Process
摘要:
Optically pure secondary alcohols were efficiently prepared via a two-step, one-pot process involving a chemical oxidative agent in combination with an enantioselective ketone reducase Rhodotorula sp. AS2.2241 in tandem. The reaction proceeded successfully with 88 similar to 99.5% enantiomeric excess in moderate to good conversions. A variety of substrates, including aromatic and aliphatic alcohols, could be tolerated.
展开
关键词:
Deracemization oxidative agent Rhodotorula sp AS2.2241 chemo-enzymatic one-pot secondary alcohols OXIDATIVE KINETIC RESOLUTION ENANTIOSELECTIVE AEROBIC OXIDATION RHODOTORULA SP AS2.2241 ASYMMETRIC REDUCTION KETONES DERACEMISATION EFFICIENT ACETOPHENONE COMPLEXES EVOLUTION
DOI:
10.2174/157017808786857516
年份:
2008


通过文献互助平台发起求助,成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用!