Stereocontrolled Synthesis of Triols Containing Four Asymmetric Centers: Application of C , O -Chelated Germyl Enolates to a Diastereoselective Aldol Reaction
摘要：
The treatment of α,β-unsaturated ketones with divalent germanium salts cleanly generated C,O-chelated germyl enolates. The aldol reactions of the chelated enolates with the aldehydes achieved a high diastereoselectivity in the construction of the five-membered aldol adducts. Furthermore, the subsequent transformation of the Ge–C bond in the aldol adduct enabled the stereocontrolled synthesis of triols bearing four asymmetric centers.
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DOI：
10.1021/acs.orglett.8b01778
年份：
2018
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