Ribosomal RNA 2 (cid:2) O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer
摘要:
Recent epitranscriptomics studies unravelled that ribosomal RNA (rRNA) 2 (cid:2) O-methylation is an additional layer of gene expression regulation high-lighting the ribosome as a novel actor of translation control. However, this major nding lies on ev-idences coming mainly, if not exclusively, from cellular models. Using the innovative next-generation RiboMeth-seq technology, we established the rst rRNA 2 (cid:2) O-methylation landscape in 195 primary human breast tumours.
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年份:
2020
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