ChemInform Abstract: Enantioselective Formal ??-Allylation of Nitroalkanes Through a Chiral Iminophosphorane-Catalyzed Michael Reaction-Julia-Kocienski Olefination Sequence
摘要：
A two-step sequence for the asymmetric formal α-allylation of nitroalkanes is disclosed. This new methodology relies on the development of a highly diastereo- and enantioselective conjugate addition of nitroalkanes to vinylic 2-phenyl-1H-tetrazol-5-ylsulfones using chiral triaminoiminophosphorane as a requisite base catalyst and subsequent Julia–Kocienski olefination under kinetic conditions.
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DOI：
10.1039/c3cc49477b
年份：
2014
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