Ionic signalling in astroglia beyond calcium
摘要：
Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca2+, Na+, Cl, H+ and possibly K+. This treatise summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. This article is protected by copyright. All rights reserved
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DOI：
10.1113/JP277478
年份：
2019
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