Solid carriers for improved delivery of hydrophobic active ingredients in pharmaceutical compositions

The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical compo...

Patel, Mahesh V，FJ Chen - US

Dosage form

The disclosure is directed to dosage forms for buccal administration of a drug and are directly applicable to the interior surfaces of the mouth. The dosag...

FH Martin，AG Tsuk - US

BISACODYL DOSAGE FORM WITH MULTIPLE ENTERIC POLYMER COATINGS FOR COLONIC DELIVERY

The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough...

Kelm，G Robert - 《Official Gazette of the United States Patent & Trademark Office Patents》

Method of grinding pharmaceutical substances

A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles ex...

JA Bruno，BD Doty，E Gustow，... - US

TRANSDERMAL DELIVERY SYSTEM

The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions; wherein the layer co...

WOOD Christopher Barry，MUNRO Hugh Semple，BOOTE Nicholas David，... - US

Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use

An active agent containing controlled release diffusion device comprising a swellable hydrogel matrix in the non-swollen state, interpenetrated with an active agent solute having a stable concentration distribution increasing in a gradie...

IL Ping，CG Ag - EP

System and method for milling materials

A system for milling at least one material, e.g., a drug. The system includes a milling apparatus and at least one milling medium. The milling apparatus includes a chamber having a rotary milling head located in it. The milling head is r...

RG Reed，D Czekai

Depyrogenating rigid grinding media, mixing with drug, autoclaving, adding surface modifier, and wet milling; bioavailability

Stable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount ...

DC Lan - US

PH-DEPENDENT SUSTAINED RELEASE, DRUG-DELIVERY COMPOSITION

A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-i...

A Moroni，W Drefko - US

Method for making uniformly sized particles from water-insoluble organic compounds

The invention involves a method for making uniformly sized particles from water-insoluble drugs or other organic compounds. First, a suitable solid organic compound is dissolved in an organic solvent, and the solution can be diluted with...

Violante Michael R.，Fischer Harry W. - EP