ChemInform Abstract: Novel One-Pot Asymmetric Cascade Approach Toward Densely Substituted Enantioenriched α-Methylene-γ-lactams
摘要：
A novel one-pot asymmetric synthesis of densely substituted alpha-methylene-gamma-lactams in favor of cis-isomer involving Zn-promoted aza-Barbier-type reaction has been well established. A wide array of alpha-methylene-gamma-lactams were obtained in high yields with excellent diastereomeric ratios from 98:2 to >99:1 and good enantioselectivities. The synthetic potential of such alpha-methylene-gamma-lactams was demonstrated by successfully oxidizing the phenol moiety to quinone in quantitative yield.
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DOI：
10.1016/j.tetlet.2014.09.045
年份：
2014
dx.doi.org
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