摘要：

In the body, millions of cells die and proliferate each day to maintain normal function andcooperation of all tissues, organs, and systems. Thus, programmed cell death, or apoptosis, is critical tosustain growth, development, and body health. The vital role of B-cell leukemia/lymphoma-2 (BCL-2)family proteins in apoptosis has been identified. The BCL-2 family includes both pro- and antiapoptoticproteins, which are structurally and functionally related, containing up to four BCL-2 homology(BH) motifs (BH1-4). There are also some nutritional factors that regulate apoptosis via the BCL-2family proteins. In this review, the BCL-2 family proteins and their apoptosis-inducing mechanismhave been discussed, along with the ...

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