Magnetically-localizable, biodegradable lipid microspheres
申请(专利)号:
EP19810302570
申请日期:
1981-06-10
公开/公告号:
EP0042249A2
公开/公告日期:
1981-12-23
申请(专利权)人:
NORTHWESTERN UNIVERSITY
摘要:
A drug carrier formulation consisting of magnetically-localizable, biodegradable lipid microspheres containing a magnetically-responsive substance, one or more diodegradable lipids and one or more nontoxic surfactants is described herein. There is also described a process for preparing such microspheres wherein the magnetically-responsive substance is wetted with surfactant and part of the lipids, then this material is added to the remaining lipids and heated to 90-100°C., water is added, the mixture is sonicated to obtain a microemulsion, which is then cooled and lyophilized to obtain the product.
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