SYNTHESIS OF 2,3-AZIRIDINO-2,3-DIDEOXY-D-LYXONO-GAMMA-LACTONE 5-PHOSPHONATE FROM D-RIBOSE, A NEW MEMBER OF THE 2,3-AZIRIDINO-GAMMA-LACTONE FAMILY OF SYNTHONS
摘要：
A formal synthesis of the novel (1S,4S,5R)-N-(benzyloxycarbonyl)-4-(diethoxyphosphinyl)methyl-3-oxa-6-azab icyclo[3.1.0]hexan-2-one 4 from D-ribose is presented. A key step involves the use of the 2,3-sulfate 12 for introduction of the C-3 azide functionality prior to aziridine ring formation. (C) 1997 Elsevier Science Ltd. [References: 31]
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关键词：
Nmda receptor antagonists Aziridine-2-carboxylic esters Cyclic sulfites Amino-acids Derivatives Analogs (r)-4-oxo-5-phosphononorvaline Aziridine-2-lactones Phosphonate Reactivity
年份：
1997
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