Aryltrimethylammonium trifluoromethanesulfonates as precursors to aryl [<SUP><FONT size=-1>18</FONT></SUP>F]fluorides: Improved synthesis of [<SUP><FONT size=-1>18</FONT></SUP>F]GBR-13119

阅读量:

20

作者:

MS HakaMR KilbournGL WatkinsSA Toorongian

展开

摘要:

Aromatic nucleophilic substitution of various trimethylammonium trifluoromethanesulfonates with [ 18 F]fluoride has been evaluated. Fluorinations were studied over a temperature range of 45-165°C, with decay corrected yields ranging from 20-80%. [ 18 F]GBR 13119, 1-[2-{(4-[ 18 F]fluorophenyl)(phenyl)methoxy}ethyl]-4-(3-phenylpropyl)piperazine, a potential radio-tracer for the dopamine uptake system, has been prepared in no-carrier-added form from 4-N,N,N,-trimethylaniliniumphenylmethanone trifluoromethanesulfonate. Purification by solid-phase techniques yielded the product in 20% decay corrected radiochemical yield and >98% radiochemical and chemical purity without HPLC.

展开

DOI:

10.1002/jlcr.2580270711

年份:

1989

通过文献互助平台发起求助,成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证,认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献,1~5分钟即可下载全文,部分资源由于网络原因可能需要更长时间,请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用