MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.
摘要：
The synthesis of a novel, potent and soluble inhibitor of human renin bearing a .beta.-amino-.alpha.,.alpha.-difluoroketone functionality is described. Its structure-activity relationship, species and protease selectivities are discussed.
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DOI：
10.1016/s0960-894x(00)80383-2
年份：
1992
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