New Strategy for the Total Synthesis of Macrosphelides A and B Based on Ring-Closing Metathesis
摘要：
[reaction: see text] A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described. The substrate of the RCM could be synthesized from readily available chiral materials, methyl (S)-(+)-3-hydroxybutyrate and methyl (S)-(-)-lactate, with a high efficiency. The RCM proceeded in the presence of Grubbs' Ru-complex, providing a new effective synthetic route to these natural products.
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DOI：
10.1021/ol0350689
年份：
2003
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来源期刊
Organic Letters
2003/09/01
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