New Strategy for the Total Synthesis of Macrosphelides A and B Based on Ring-Closing Metathesis

作者:

Y MatsuyaT KawaguchiH Nemoto

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摘要:

[reaction: see text] A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described. The substrate of the RCM could be synthesized from readily available chiral materials, methyl (S)-(+)-3-hydroxybutyrate and methyl (S)-(-)-lactate, with a high efficiency. The RCM proceeded in the presence of Grubbs' Ru-complex, providing a new effective synthetic route to these natural products.

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DOI:

10.1021/ol0350689

年份:

2003

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