摘要：

The aim was to determine the characteristics of patients who developed Cutibacterium acnes spinal implant-associated infection (SIAI) and the associated risk factors.We conducted two parallel case-control studies comparing 59 patients with SIAI caused by C.acnes (cases 1) and 93 patients with SIAI caused by other microorganisms (cases 2) diagnosed during 2010-2015 with 302 controls who underwent spinal instrumentation without subsequent infection.Late-onset infections (median time to diagnosis, 843days versus 23days; p2 (aOR 2.47, 95% CI 1.17-5.29, p 0.02), and thoracic instrumentation (aOR 16.1, 95% CI 7.57-37.0, pFuture therapeutic and prophylactic studies on C.acnes SIAI should focus on young, thin patients who undergo spinal instrumentation procedures involving the thoracic spine.

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