Perivascular epithelioid cell tumor (PEComa) with TFE3 gene rearrangement: clinicopathological, immunohistochemical, and molecular features.
摘要：
Perivascular epithelioidellumors (PEComas)aveeen increasinglyssociated with geneearrangementfheranscriptionactor E3 (TFE3). We presenthreeasesf PEComa withFE3 genebnormality detectedy immunohistochemistry (IHC)ndluorescence inituybridization (FISH).heirlinicaleatures, pathologicalorphology,nd prognosis were investigated.istologically,heumors inhesehreeaseshowed predominantly epithelioidellsrranged in nestsrheetseparatedy delicate vascular network, withinwofhehreeases nucleartypia,itoticigures,nd necrosis.llhreeaseshowedtrongFE3ndathepsin K immunoreactivitynd weakotrongeactivityorMB45.neasef PEComa withFE3 geneusion exhibitedenignourse.hetherwoasesf PEComa withothFE3ranslocationnd X-chromosome polysomy wereistologicallyalignantndhowedggressive growth. Inummary,nusualasesf PEComa withFE3 geneearrangementight presentalignantistologicaleaturesndggressivelinicalehavior.uresultsddasesohe literaturend describenssociationf polysomy withggressiveehavior.
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年份：
2014
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