摘要：

Aerosol therapy is a local drug therapy widely used in the otorhinolaryngology that is safe and effective. Its greatest challenge lies in the delivery of the aerosolized drug to the target site. The effectiveness of aerosol therapy for chronic sinusitis can be enhanced by overcoming the following problems: 1) Problems related to nebulizers, the device used to generate aerosols 2) Problems related to the drug used 3) Biological problems in the patient Specifically, the points that must be considered include the following: 1) Maximizing pressure changes in the nasal cavity and paranasal sinuses: the perspective of compression and vibration loading 2) Reducing the sizes of the particles delivered through the narrow sinus ostia: the perspective of particle size 3) Increasing the positive pressure used during administration of the drug solution within the range tolerated by the body: the perspective of flow rate 4) Ensuring that delivery into the nasal cavity is not obstructed by nasal hair, and switching from laminar flow to turbulent flow in order to enable aerosol particles to attach closely to the surface of the middle meatus and nasal mucosa: the perspective of the nozzle 5) Using the most useful drug for the illness 6) Ensuring that the sinus ostia are sufficiently large: enlargement by surgery 7) Preparation for inhalation: secretion removal 8) Convenience 9) Ease of maintenance and inspection

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