LOW-MELTING MOLDABLE PHARMACEUTICAL EXCIPIENT AND DOSAGE FORMS PREPARED THEREWITH
申请(专利)号:
AU19890044228
申请日期:
1989-10-12
公开/公告号:
AU625683B2
公开/公告日期:
1992-07-16
申请(专利权)人:
ZETACHRON, INC.
摘要:
An exicipient for a pharmaceutical compound which melts at body temperature but will not spontaneously deform at higher temperatures encountered in shipment and storage comprises: -Low MW Polyethylene glycol 75-90% -(M.P. about 37 DEG C.) -Medium to high MW polyethylene glycol 0-4% -Long chain saturated carboxylic acid 0-4% -Polyethylene oxide 0-4% -(MW 100,000-5,000,000) -Colloidal silica 10-20%. - The excipient is particularly advantageous for the preparation of dosage forms for buccal administration of pharmaceutical compounds.
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