摘要：

Methods of Enhancing Drug Release and Therapeutic Agent Effectiveness The present invention in a space provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing the effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising albumin-containing nonaparticles and a poorly soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a patient selection method for treating a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising albumin-containing nonaparticles and a poorly soluble drug. such as a taxane based on one or more target tissue characteristics that correlates or indicates the ability to achieve enhanced uptake of the therapeutic agent as a result of co-administration of the taxane nanoparticle composition in the target tissue (referred to as "the drug uptake capacity) Also provided are pharmaceutical compositions, article of manufacture, and kits useful to physicians described herein in this patient application.

展开