摘要：

Iba-1 (Ionized calcium binding adaptor molecule 1), also known as Aif-1, is a 17 kDa microglia-specifi c protein which is encoded by AIF1 gene. Iba-1 is a marker associated with activated microglia and is involved in key functions such as phagocytosis and migration, being an important structure of the cytoskeleton. Previous studies showed that Iba-1 forms complexes with L-fi mbrin in membrane ruffl es which are involved in modulating actin reorganization to facilitate cellular motility and phagocytosis by microglia (Ohsawa et al., 2004). The goal of this study was to evaluate how the silencing of Iba-1 in BV2 cells could change the characteristic functions of microglia.

展开