摘要：

Diabetes mellitus,an epidemic metabolic disorder characterized by high blood glucose level associated with various microvascular complications,affects the human health seriously.With the advance of the pathogenesis of diabetic research,many drugs with new targets and new mechanism are explored.Among them,G protein-coupled receptor 119(GPR119) activator has increasingly been come under recognition.Here,several types of GPR119 agonists such as six-membered heterocyclic ring-based agonists,five-membered heterocyclic ring-based agonists,bicyclic core-based agonists and linear core-based agonists were reviewed.

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