Androgen Receptor Signaling in Androgen-Refractory Prostate Cancer

Prostate cancer is the second most prevalent cancer in males in the United States. Standard therapy relies on removing, or blocking the actions of, androge...

ME Grossmann，H Huang，DJ Tindall - 《Journal of the National Cancer Institute》

Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer

Advanced prostate tumors, which are androgen dependent, are often initially treated in the clinic with hormone ablation therapy, either through surgical ca...

KR Lamont，DJ Tindall - 《Molecular Endocrinology》

Androgen receptor signaling in androgen-refractory prostate cancer.

Prostate cancer is the second most prevalent cancer in males in the United States. Standard therapy relies on removing, or blocking the actions of, androge...

M E，Grossmann，Huang，... - 《Journal of the National Cancer Institute》

Gene Expression in Prostate Cancer Cells Treated With the Dual 5 Alpha-Reductase Inhibitor Dutasteride

We sought preclinical data on the cellular and molecular effects of dutasteride in androgen-responsive, human prostate cancer (PCa) cells to better underst...

Lucy，J.，Schmidt，... - 《Journal of Andrology》

Curcumin sensitizes prostate cancer cells to tumor necrosis factor–related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-κB through suppre...

Epidemiologic studies suggest that diet rich in plant-derived foods plays an important role in the prevention of prostate cancer. Curcumin, the yellow pigm...

D Deeb，J Hao，X Gao，... - 《Molecular Cancer Therapeutics》

Prostate growth and inflammation

There is emerging evidence that prostatic inflammation may contribute to prostate growth either in terms of hyperplastic (BPH) or neoplastic (PC) changes. ...

A Sciarra，G Mariotti，S Salciccia，... - 《Journal of Steroid Biochemistry & Molecular Biology》

Knowledge and Use of Finasteride for the Prevention of Prostate Cancer

BACKGROUND: The knowledge about and use of chemopreventive agents for prostate cancer by physicians has not been described. The Prostate Cancer Prevention ...

RJ Hamilton，LC Kahwati，LS Kinsinger - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno-mediated inflammation.

Benign prostatic hyperplasia (BPH), a highly prevalent prostatic condition, could involve an inflammatory component in disease pathogenesis. In this study,...

Giuseppe，Penna，Benedetta，... - 《Journal of Immunology》

Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer.

Human prostate adenocarcinoma (CaP) and benign prostatic hyperplasia (BPH) have epithelial and stromal cell origins, respectively. To determine whether the...

DR Bauman，S Stephan，DM Peehl，... - 《Endocrinology》

Androgen receptor levels are upregulated by Akt in prostate cancer.

Multiple lines of evidence suggest a functional link between the androgen receptor (AR) and the serine/threonine kinase Akt in the development and progress...

S Ha，R Ruoff，N Kahoud，... - Endocrine-related cancer