摘要：

NEW MATERIAL: A compound of formula I [X is R 3 CO (R 3 is 1-8C alkyl, 6-10C aryl or tolyl); R 1 is cyclohexylmethyl; R 2 is isopropyl; W is C(OH)H-CH 2 ; A is formula II (R 4 is 1-8C alkyl) peresent in the D-, L- or DL-form, preferably in the L-form; Y is NHR 5 (R 5 is formula III)] or its salt. EXAMPLE: N α -{N δ -[(1-Oxo)ethyl-[1-(5-S-amino-6-cyclohexyl-4-S-hydroxy-2-(1- methyl)ethylhexanolyl]]-S-isoleucynyl}-2-pyridylmethylamide. USE: Antibiotics in humans and domestic animals exhibiting very strong activity against retrovirus. PROCESS: For example, a compound of formula IV is acylated with an acetic anhydride in a suitable solvent in the presence of a base to give the exemplified compound. COPYRIGHT: (C)1991,JPO

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