摘要：

Problem to be solved: to provide a fentanyl containing transdermal administration agent capable of reducing the decrease in analgesic effect occurring on the third day after pasting. The present invention comprises a support, a drug containing layer stacked on the support, a drug control membrane which is laminated on the drug containing layer and is permeable through the drug, and an adhesive layer stacked on the drug control film The drug containing layer comprises an adhesive and a drug containing particle comprising fentanyl or its pharmaceutically acceptable salt and dissolving agent dispersed in the adhesive When the percutaneous administration was affixed to the skin for 72 hours, the concentration of fentanyl or its pharmaceutically acceptable salt during the period of 48 to 72 hours was greater than 0.2 ng / ml or more than A transdermal administration agent with an adjustable coefficient of acc48-72 of less than 35% is available. Diagram

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