Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity
摘要：
Lysophospholipase D (lysoPLD), also known as autotaxin (ATX), is an important source of the potent mitogen lysophosphatidic acid (LPA). Two fluorogenic substrate analogues for lysoPLD were synthesized in nine steps from (S)-PMB-glycerol. The substrates (FS-2 and FS-3) show significant increases in fluorescence when treated with recombinant ATX and have potential applications in screening for this emerging drug target.
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关键词：
LYSOPHOSPHATIDIC ACID OVARIAN-CANCER AUTOTAXIN GROWTH PHOSPHODIESTERASE IDENTIFICATION ENZYME PLASMA FAMILY ASSAY
DOI：
10.1021/ol060414i
年份：
2006
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