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None declared. Disclosure AS has ownership interest as an inventor for a patent entitled 'Colorectal cancer classification with differential prognosis and personalised therapeutic responses' (patent number PCT/IB2013/060416). AS received research funding from Bristol-Myers Squibb, Merck KGaA and Pierre Fabre. All remaining authors have declared no conflicts of interest. References 1 Dienstmann R , Mason MJ , Sinicrope FA et al. Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study . Ann Oncol 2017 ; 28 ( 5 ): 1023 – 1031 . 2 Labianca R , Nordlinger B , Beretta GD et al. Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up . Ann Oncol 2013 ; 24(Suppl 6 ): vi64 – 72 . 3 Sadanandam A , Lyssiotis CA , Homicsko K et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy . Nat Med 2013 ; 19 ( 5 ): 619 – 625 . 4 De Sousa E Melo F , Wang X , Jansen M et al. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions . Nat Med 2013 ; 19 ( 5 ): 614 – 618 . 5 Marisa L , de Reyniès A , Duval A et al. Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value . PLoS Med 2013 ; 10 ( 5 ): e1001453 . 6 Roepman P , Schlicker A , Tabernero J et al. Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition . Int J Cancer 2014 ; 134 ( 3 ): 552 – 562 . 7 Schlicker A , Beran G , Chresta CM et al. Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines . BMC Med Genomics 2012 ; 5 ( 1 ): 1 – 15 . 8 Budinska E , Popovici V , Tejpar S et al. Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer . J Pathol 2013 ; 231 ( 1 ): 63 – 76 . 9 Guinney J , Dienstmann R , Wang X et al. The consensus molecular subtypes of colorectal cancer . Nat Med 2015 ; 21 ( 11 ): 1350 – 1356 . 10 Fontana E , Eason K , Homicsko K , Sadanandam A. Molecular classification of colon cancer: perspectives for personalized adjuvant therapy . Curr Colorectal Cancer Rep 2016 ; 12 ( 6 ): 296 – 302 . 11 Lenz HJ , Ou FS , Venook AP et al. Impact of consensus molecular subtype on survival in patients with metastatic colorectal cancer: results from CALGB/SWOG 80405 (Alliance) . J Clin Oncol 2019 ; 37 ( 22 ): 1876 – 1885 . 12 Song N , Pogue-Geile KL , Gavin PG et al. Clinical outcome from oxaliplatin treatment in stage II/III colon cancer according to intrinsic subtypes: secondary analysis of NSABP C-07/NRG oncology randomized clinical trial . JAMA Oncol 2016 ; 2 ( 9 ): 1162 – 1169 . 13 Fontana E , Eason K , Cervantes A et al. Context matters-consensus molecular subtypes of colorectal cancer as biomarkers for clinical trials . Ann Oncol 2019 ; 30 ( 4 ): 520 – 527 . 14 Dienstmann R , Vermeulen L , Guinney J et al. Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer . Nat Rev Cancer 2017 ; 17 ( 2 ): 79 – 92 . 15 Mlecnik B , Tosolini M , Kirilovsky A et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction . J Clin Oncol 2011 ; 29 ( 6 ): 610 – 618 . 16 Calon A , Lonardo E , Berenguer-Llergo A et al. Stromal gene expression defines poor-prognosis subtypes in colorectal cancer . Nat Genet 2015 ; 47 ( 4 ): 320 – 329 . 17 Dienstmann R , Villacampa G , Sveen A et al. Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer . Ann Oncol 2019 ; 30(10): 1622–1629. 18 Pages F , Mlecnik B , Marliot F et al. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study . Lancet 2018 ; 391 : 2128 – 2139 . 19 Petrelli F , Tomasello G , Borgonovo K et al. Prognostic s

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