摘要：

An 80-year-old man was referred to our department because of lymphocytosis. His white cell count was 17.1 x 103/uL, with 64% prolymphocytes. He did not exhibit splenomegaly or lymphadenopathy. Prolymphocytes were CD5~+, CD10~-, CD19~+, CD20~+, CD21~(+weak), CD22~+, CD23~-, and HLA-DR~+, and expressed mudelta/lambda cell-surface immunoglobulins. G-banding and fluorescence in situ hybridization using c-MYC and immunoglobulin heavy-chain (IgH) gene probe revealed that leukemia cells carried the t(8;14)(q24;q32)/c-MYC-IgHfusion gene, and breakage and reunion occurred within the non-coding region of c-MYC exon 1 as well as the a switch region of IgH. Nine months after the initial presentation, the patient's hemoglobin level fell to 5.7 g/dL. Coombs' test was positive and marked hypoplasia of erythroid precursors was detected in his bone marrow.

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