Human Fas ligand: gene structure, chromosomal location and species specificity

Fas ligand (FasL) is a 40 kDa type II membrane protein belonging to the tumor necrosis factor family, which induces apoptosis by binding to its receptor, F...

T Tomohiro，T Masato，I Johji，... - 《International Immunology》

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77

Berkeley Electronic Press Selected Works

SWS Schneider，ZG Lui，KA Mclaughlin，... - Nature

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase.

Tumor necrosis factor alpha (TNF alpha) has multiple biological functions including the prolonged activation of the collagenase and c-jun genes, which are ...

JK Westwick，C Weitzel，A Minden，... - 《Journal of Biological Chemistry》

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.

Examines a dual specificity kinase that activates the Jun kinases (JNK) and p38 or Mpk2. Dependence of Ras-dependent protein kinase cascade on the protein ...

Lin，Anning，Minden，... - 《Science》

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

NF-kappa B and AP-1 represent distinct mammalian transcription factors that target unique DNA enhancer elements. The heterodimeric NF-kappa B complex is ty...

B，Stein，A，... - 《Embo Journal》

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids

Activation of T cell hybridomas induces a G1/S cell cycle block and apoptosis. We isolated a variant of the 2B4.11 T cell hybridoma that, when activated vi...

Yang，Y. - 《Journal of Experimental Medicine》

The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression

T lymphocytes undergo apoptosis in response to cellular stress, including UV exposure and gamma irradiation. However, the mechanism by which stress stimuli...

M Faris，N Kokot，K Latinis，... - 《Journal of Immunology》

Radiation and stress-induced apoptosis: A role for Fas/Fas ligandinteractions

The lpr gene encodes a defective form of Fas, a cell surface protein that mediates apoptosis. This defect blocks apoptotic deletion of autoreactive T and B...

EA Reap，K Roof，K Maynor - 《Proceedings of the National Academy of Sciences of the United States of America》

Daunorubicin Activates NFκB and Induces κB-dependent Gene Expression in HL-60 Promyelocytic and Jurkat T Lymphoma Cells

The anthracycline antibiotic, daunorubicin, can induce programmed cell death (apoptosis) in cells. Recent work suggests that this event is mediated by cera...

 - 《Journal of Biological Chemistry》

Cross-coupling of the NF-kappaB p65 and Fos/Jun transcription factors produces potentiated biological function

The anthracycline antibiotic, daunorubicin, can induce programmed cell death (apoptosis) in cells. Recent work suggests that this event is mediated by cera...

Stein，B.，Baldwin，... - 《Embo Journal》