摘要：

In this study, we achieved an eight-step enantioselective synthesis of ()-lamellodysidine A, a structurally intriguing sesquiterpene natural product featuring a 5/5/6/6-fused tetracyclic skeleton that was obtained from the marine sponge Lamellodysidea herbacea . The key to the synthesis is a cascade reaction that includes an intramolecular Diels–Alder reaction. In addition, single-crystal X-ray crystallographic analysis of the synthetic ()-lamellodysidine A clearly confirmed the proposed stereochemistry and absolute configuration.

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