摘要：

The development of tissue engineering structures (scaffolds) for the reconstruction of bone tissue defects is the relevant task of modern biomedical materials science. Compared to metal-based structures, polymer constructs provide numerous advantages, among them - better processibility and metallosis avoidance. Owing to its high mechanical performance and biocompatibility, polyetherketoneketone (PEKK) became a promising material for the development of such structures. Previously, a method for the immobilization of hydroxyapatite (HAp) on PEKK surface was proposed by our group for the enhancement of stem cell adhesion. In the present study, we propose a single-step method of HAp immobilization on the surface of 3D-printed porous PEKK implants. The proposed approach allowed to preserve the morphology (pore diameter, width of the printed lines) of the pristine implants. With that, up to 35.0+-14.0 % of the sample surface were coated with HAp particles, which resulted in improved hydrophilicity (0 degrees water contact angle). The calcium and phosphorus content on the surface of the modified samples was up to 17.4+-4.1 and 8.0+-1.7 wt. %, respectively. Importantly, the proposed modification preserved compressive strength of the 3D-printed porous PEKK implants. HAp immobilization provided better adhesion of stem cells (from 121+-40 cells/mm2 to 234+-8 cells/mm2) and induce their osteogenic differentiation.

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