摘要：

The invention discloses a preparation method of olmesartan medoxomil,Which is characterized by reacting ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (I) and N-(triphenylmethyl)-5-(4'-bromoethylbiphenyl-2-)tetrazole (II) by a one-pot process to directly obtain lithium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(triphenylmethyltetrazolyl-5-yl)phenyl]phenyl}methylimidazol-5-carboxylate (IV). The invention has the advantages of mild reaction conditions, fewer byproducts, high purity of the end product, high total yield, high safety and environmental protection, and is suitable for industrial production; and by using the one-pot process, the invention is simpler to operate, saves the time and lowers the cost.

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