摘要：

Benzothiazine-substituted indole of general formula (I), methods, R 1 , R 2 and R 4 are each independently is selected from hydrogen, chloro, fluoro, amino, nitro, cyano, CHO, (C 1 -C 3 ) alkyl, perhalo (C 1 -C 3 ) alkyl, (C 1 -C 3 ) alkoxy, aryl, aralkyl , aralkoxy, (C 5 -C 7 ) heterocyclyl, (C 5 -C 7 ) heterocycloalkyl, (C 5 -C 7 ) heterocyclyloxy, acyl, acetyl, alkylamino, aminoalkyl, amide, hydroxyalkyl , carboxylic acids and derivatives thereof, R 3 is selected from hydrogen, (C 1 -C 3 ) alkyl, aryl and carboxylic acid and derivatives thereof, said method comprising using a suitable catalyst and a solvent, the general formula (II) compound (i.e. substituted 1-benzenesulfonyl-7-bromo -1H- indole) cyclization, in which R 1 , R 2 , R 3 and defines 4 R supra.

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