摘要：

In this review,the pivotal achievements and recent advances in catalytic asymmetric aza-DAR reported up to 2020 are retrospectively considered and their potency for enantioselective synthesis of useful chiral piperidine,quinoline,pyridazine,oxazine and oxadiazine derivatives and fused compounds of higher molecular complexity bearing these pharmacology-relevant heterocyclic scaffolds is demonstrated. The reported data are systematized according both to key electron transfer modes(normal or invers electron demand reactions)and to main types of attainable heterocyclic products. Of significant attention are an analysis of activation strategies(complexation,enamine or enolate formation,Hbonding,etc.)applicable to reactions with particular types of dienes and dienophiles and identification of plausible reaction pathways(either concerted or stepwise)over stereoselective cyclization processes. The review contains 310 references and 122 synthetic schemes. 1. Introduction 2. Normal Electron Demand Asymmetric Aza-Diels-Alder Reaction 2.1. Synthesis of N-Heterocycles Bearing Hydrogenated Pyridine Fragments 2.2. Synthesis of Hydrogenated Pyridazine Derivatives 2.3. Synthesis of Hydrogenated Oxazine Derivatives 3. Inverse Electron Demand Asymmetric Aza-Diels-Alder Reactions 3.1. Synthesis of Tetrahydropyridine Derivatives 3.2. Synthesis of Tetrahydroquinoline Derivatives 3.3. Synthesis of Hydrogenated Diazine Derivatives 3.4. Synthesis of Hydrogenated Oxazine and Oxadiazine Derivatives 4. Summary and Outlook.

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