Potent triazolyl-proline-based inhibitors of HCV NS3 protease.
摘要：
The design and synthesis of tripeptide-based inhibitors of the HCV NS3 protease containing a novel P2-triazole is described. Replacement of the P2 quinoline with a triazole moiety provided a versatile handle which could be expediently modified to generate a diverse series of inhibitors. Further refinement by the incorporation of an aryl-substituted triazole and replacement of the P1 acid with an acyl sulfonamide ultimately provided inhibitors with interesting cellular activity.
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DOI：
10.1016/j.bmcl.2008.04.012
被引量：
年份：
2008
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