Structure and chemical properties of ptilomycalin A

来自 ACS

阅读量:

46

作者:

I OhtaniT KusumiH KakisawaY KashmanS Hirsh

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摘要:

The structure of ptilomycalin A (1), a marine alkaloid possessing potent antiviral and antibiotic activites, has been determined on the basis of NMR analyses of its trifluoroacetyl (TFA) derivative (2). It has a unique structure consisting of a polycyclic guanidine and a spermidine group, each of which is linked to a 16-hydroxyhexadecanoic acid moiety. The rotational isomerism of the acylated sperimidine moiety of 2 has been studied by comparing the NMR properties of the synthetic trifluoroacetyl derivatives of spermidine (5), dipropylenetriamine (11), diethylenetriamine (12), and pentylamine (13). From these experiments, a plausible conformation of 2 a

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DOI:

10.1021/ja00048a018

被引量:

471

年份:

1992

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来源期刊

Cheminform
1992/10/01

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