Brindley DN, Lin FT, and Tigyi GJ (2013) Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim ...
DN Brindley，FT Lin，GJ Tigyi - Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Lysophosphatidate promotes cancer cell survival, growth, migration, invasion, metastasis, and resistance to chemotherapy and radiotherapy. The present work ...
ATX (autotaxin) is a secreted lysophospholipase capable of catalysing the formation of the bioactive lipid mediator LPA (lysophosphatidate) from LPC (lysop...
There is an accumulating body of evidence linking the secreted enzyme autotaxin (ATX) and its product lysophosphatidate (LPA) to tumor progression, metasta...
Cancer research 2015;75:532-543. 14 [40] Brindley DN, Lin FT, Tigyi GJ. Role of the autotaxin-lysophosphatidate axis in 15 cancer resistance to chemotherapy and radiotherapy. Biochimica et biophysica acta 16 2013;1831:74-85. 17 ...
Overcoming and preventing cancer therapy resistance is the most pressing challenge in modern breast cancer management. Consequently, most modern breast can...
Breast cancer patients are usually treated with multiple fractions of radiotherapy (RT) to the whole breast after lumpectomy. We hypothesized that repeated...
