SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
摘要：
Resveratrol's ability to improve mitochondrial function requires SIRT1 invivo Moderate doses of resveratrol activate AMPK and raise NAD+ in a SIRT1-dependent manner Activation of AMPK in the absence of SIRT1 does not improve mitochondrial function Overexpression of SIRT1 mimics resveratrol's effects on AMPK and mitochondria
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关键词：
Animals Mice, Inbred C57BL Mice, Knockout Mice Muscle, Skeletal Mitochondria Hepatocytes Cells, Cultured Stilbenes NAD
DOI：
10.1016/j.cmet.2012.04.003
被引量：
年份：
2012
Taylor & Francis
Elsevier
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