Synthesis and structure of biologically active ferrocenylalkyl polyfluoro benzimidazoles
摘要：
The title compounds were synthesized in quantitative yields by interacting α-hydroxyalkyl ferrocenes with polyfluoroalkyl benzimidazoles in an aqueous-organic medium in the presence of HBF 4 . The resulting diastereomers and enantiomers were resolved using HPLC on silica bonded chiral stationary phases based on chiral cyclodextrins and cyclic antibiotics. The X-ray determination of molecular and crystal structure of 1-ferrocenylmethyl-2-(trifluoromethoxyfluoromethyl)benzimidazole ( 1 ) was carried out.
展开
关键词：
Ferrocene derivatives α-Ferrocenylalkylation Benzimidazole Polyfluoro-benzimidazoles X-ray crystal structure Separation of enantiomers HPLC Chiral cyclodextrin sorbents
DOI：
info:doi/10.1016/S0022-328X(98)01097-3
被引量：
年份：
1999
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
