Novel melanocortin receptor agonists and antagonists
The present invention relates to novel aromatic amines of general formula (I) and to the use of these amines for the treatment of obesity, anorexia, inflammation, mental disorders an other diseases associated with the melanocortin recept...
T Lundstedt，A Skottner，E Seifert，... - US
ANHYDRIDE MODIFIED CANTHARIDIN ANALOGUES USEFUL IN THE TREATMENT OF CANCER
Anhydride modified cantharidin analogues useful in the treatment of certain forms of cancer also methods for the screening for anti-cancer activity of these analogues and/or their ability to sensitise cancer cells to cancer treatment. Th...
M Adam，SAKOFF JENNETTE A.，A Stephen，... - WO
Therapeutic methods of reducing cholesterol accumulation
Methods of reducing the cholesterol accumulation in a subject, including methods of reducing cholesterol synthesis and methods of increasing cholesterol degradation. Cholesterol synthesis is inhibited by administering a compound capable ...
NB Javitt - US
Method and compositions for treating gastric hyperacidity while diminishing the likelihood of producing vitamin deficiency
A method for treatment of a human for gastric hyperacidity while diminishing the likelihood of producing vitamin deficiency is disclosed, the method comprising administering a therapeutically effective amount of one or more substances th...
RC Theuer - US
Treatment and prevention of joint disease
The invention provides compositions and methods for preserving, prolonging, or augmenting joint lubrication by contacting a tissue of a joint such as a knee, elbow, or other articulating joint, with a tribonectin and an inhibitor of a pr...
GD Jay，KA Elsaid - US
Anti-platelet aggregation compositions
A combination of nimesulide and a sub-therapeutic dose of aspirin provides effective anti-platelet aggregation treatment.
SA Saeed，SO Saeed - US
3-Aminoindazoles
Novel 3-aminoindazoles of the formula (I) are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, card...
D Dorsch，LT Burgdorf，R Gericke，...
METHOD FOR TREATMENT OF PANCREATITIS
A method for treating acute or chronic pancreatitis in a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor.
LA Tartaglia，TM Barnes，RM Coopersmith，... - US
SR-BI antagonist and use thereof as contraceptives and in the treatment of steroidal overproduction
SR-BI is present on the membranes of hepatocytes and steroidogenic tissues, including the adrenal gland, testes, and ovaries, where it mediates the uptake and transport of cholesteryl ester from high density lipoproteins. It has been dem...
M Krieger - EP
2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs
This invention discloses 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20S,22E,25R)-1伪,25-dihydroxyvitamin D 3 , and pharmaceutical uses therefor. This compound exhibits transcription...
DELUCA, Hector, F.，CHIELLINI, Grazia，GRZYWACZ, Pawell，... - US
