Alpha-B-Crystallin in Neuropathology
摘要：
alpha;B-Crystallin, which has homology with the small heat shock proteins, is the basic subunit of α-crystallin, a major component of the vertebrate eye lens. These crystallins have for a long time been thought to be absolutely lens specific. However, about a decade ago αB-crystallin has been detected extralenticularly in many tissues among which the central nervous system. Under pathological conditions the expression level of αB-crystallin frequently increases. For this reason it is considered to be a useful marker in a variety of neurodegenerative diseases. In this mini-review, a number of typical neurodegenerative disorders is dealt with in which αB-crystallin may play a role.
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DOI：
10.1159/000027468
被引量：
年份：
2000
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