Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione.
摘要：
A line RT4 was sham-treated with buffer or treated with (VC) alone, alone (VK(3)), or a combination of :(VC+VK(3)) for 1, 2, and 4 h. Cytotoxic damage was found to be treatment-dependent in this sequence: VC+VK(3)>VC>VK(3)>sham. The combined treatment induced the greatest oxidative stress, with early injury affecting the cytoskeletal architecture and contributing to the self-excisions of pieces of freed from . Additional damage, including a reduction in size, alterations, nuclear damage, and nucleic acid as well as compromised integrity, is caused by reactivation of and the redox cycling of VC or VC+VK(3). In addition, caused by VC+VK(3) treatment as well as by prolonged VC treatment is consistent with demise by autoschizis, not apoptosis. This report confirms and complements previous observations about this new mode of . It supports the contention that a combination of VC+VK(3), also named Apatone, could be co-administered as a nontoxic adjuvant with radiation and/or chemotherapies to kill and other without any supplementary risk or side effects for patients.
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DOI：
10.3109/01913121003662304
被引量：
年份：
2010
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