Drugs from the deep: marine natural products as drug candidates.
摘要：
In recent years, marine natural product bioprospecting has yielded a considerable number of drug candidates. Most of these molecules are still in preclinical or early clinical development but some are already on the market, such as cytarabine, or are predicted to be approved soon, such as ET743 (Yondelis). Research into the ecology of marine natural products has shown that many of these compounds function as chemical weapons and have evolved into highly potent inhibitors of physiological processes in the prey, predators or competitors of the marine organisms that use them. Some of the natural products isolated from marine invertebrates have been shown to be, or are suspected to be, of microbial origin and this is now thought to be the case for the majority of such molecules. Marine microorganisms, whose immense genetic and biochemical diversity is only beginning to be appreciated, look likely to become a rich source of novel chemical entities for the discovery of more effective drugs.
展开
DOI：
10.1016/S1359-6446(03)02713-2
被引量：
年份：
2003
Taylor & Francis
Elsevier
国家科技图书文献中心
(权威机构)
Semantic Scholar
(全网免费下载)
掌桥科研
查看更多
万方医学
dx.doi.org
Ingenta
Europe PMC
NCBI
NCBI
NRC Research Press
ResearchGate
EureKaMag.com
(全网免费下载)
ResearchGate
(全网免费下载)
EBSCO
scienceopen.com
onAcademic
mendeley.com
yadda.icm.edu.pl
en.zl50.com
baywood.metapress.com
journals.indexcopernicus.com
deepdyve.com
mysciencework.com
pherobase.com
faculty.ksu.edu.sa
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
