Inhibition of monoamine oxidase B in the brains of smokers

来自 EBSCO

喜欢 0

阅读量：

106

作者：

JS Fowler，GJ Wang，N Pappas，J Logan，Macgregor R. Alexoff D，C Shea，D Schlyer，AP Wolf，Warner D，Zezulkova I. Cilento R

展开

摘要：

THE massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking 1 . Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smoking is so prevalent in psychiatric disorders 2 and is associated with a decreased risk of Parkinson's disease 3 . Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC 1.4.3.4) relative to non-smokers or former smokers. MAO B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviours as well as movement. MAO B inhibition is therefore associated with enhanced activity of dopamine 4 , as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species 5 . We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking.

展开

关键词：

L-deprenyl Parkinsons-disease Cigarette smokers Tobacco-smoke Neurotoxicity Striatum Rats

DOI：

10.1038/379733a0

被引量：

3129

年份：

1996